This Plain Language Summary of Publication article (PLSP) from Current Medical Research and Opinion examined how researchers used population pharmacokinetics modeling to study aripiprazole behavior in people with schizophrenia. They compared blood levels of aripiprazole in patients who started treatment with either one or two monthly injections. The goal was to determine if a two-injection start could achieve therapeutic drug levels without needing 14 days of oral aripiprazole tablets, which is required when starting with a single injection.

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This PLSP is based on an article called ‘An alternative start regimen with aripiprazole once-monthly in patients with schizophrenia: population pharmacokinetic analysis of a single-day, two-injection start with gluteal and/or deltoid intramuscular injection’ and was published in the Current Medical Research and Opinion.

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