This Plain Language Summary of Publication article (PLSP) from Future Virology, discusses how ritonavir, a drug used in some COVID-19 treatments, can interact with other medications, potentially reducing effectiveness or causing harmful side effects like irregular heartbeat, low blood pressure, or breathing problems. Serious interactions can be life-threatening, so patients taking certain medications may need alternative COVID-19 treatments. Two real-world studies aimed to determine the percentage of adults in the U.S. who might experience drug-drug interactions if prescribed ritonavir-containing COVID-19 treatments, and to identify adults with COVID-19 at risk of such interactions.

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This PLSP is based on two articles called ‘Prevalence of Potential Drug-drug Interactions With Ritonavir-containing COVID-19 Therapy in the United States: An Analysis of the National Health and Nutrition Examination Survey’ published in Clinical Therapeutics, and ‘Prevalence of potential drug-drug interactions with ritonavir-containing COVID-19 therapy’ published in JMCP.

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