atherosclerosis

17th Jul 2025

Plain language summary: the long-term benefits and safety of evinacumab treatment for people with a severe inherited cholesterol disorder

This is a summary of the article describing the results of the ORION-10 and ORION-11 studies, which was published in the New England Journal of Medicine in April 2020. The studies included adult participants with atherosclerotic cardiovascular disease (ASCVD). ASCVD happens when the blood vessels that carry blood from the heart to other areas of the body are blocked by fatty build-up (plaque) causing a heart attack, stroke, or other problems. High levels of low-density lipoprotein cholesterol (LDL cholesterol) in the blood can cause this fatty build-up. ORION-11 also included participants who were at high risk for ASCVD due to other conditions or high cholesterol that runs in the family

7th Jun 2023

Plain Language Summary: the ORION-10 and ORION-11 studies look at how well inclisiran works in people with high cholesterol