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biliary tract cancer

15th Aug 2024

Results from the phase 2b HERIZON-BTC-01 study of zanidatamab in HER2-amplified biliary tract cancer: a plain language summary

This is a summary describing the results of a Phase III study called TOPAZ-1. The study looked at treatment with durvalumab (a type of immunotherapy) and chemotherapy to treat participants with advanced biliary tract cancer (BTC). Advanced BTC is usually diagnosed at late stages of disease, when it cannot be cured by surgery. This study included participants with advanced BTC who had not received previous treatment, or had their cancer come back at least 6 months after receiving treatment or surgery that aimed to cure their disease. Participants received treatment with durvalumab and chemotherapy or placebo and chemotherapy. The aim of this study was to find out if treatment with durvalumab and chemotherapy could increase the length of time that participants with advanced BTC lived, compared with placebo and chemotherapy.
6th Oct 2023

The TOPAZ-1 study: a plain language summary describing durvalumab and chemotherapy for advanced biliary tract cancer

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