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breast

22nd Jan 2025

Plain language summary of the DESTINY-Breast04 study: Trastuzumab deruxtecan for previously treated HER2-low advanced breast cancer

23rd Sep 2024

A plain language summary of the CAPItello-291 study: Capivasertib for advanced hormone receptor-positive breast cancer.

This is a summary of a publication about the DESTINY-Breast03 study, which was published in the New England Journal of Medicine in March 2022. The study included 524 adults with advanced breast cancer that is HER2-positive, which means it has high levels of a protein called HER2. All of the participants in this study had their cancer worsen after previously receiving treatment. The treatment that was previously given to participants was a combination of a drug called trastuzumab with a type of chemotherapy called a taxane. The researchers wanted to know whether a drug called trastuzumab deruxtecan (T-DXd) could improve participants’ cancer more than the standard treatment. The standard treatment is a drug called trastuzumab emtansine (T-DM1). The researchers looked at the results of this study before it was finished. This is a summary of those results.
22nd Jan 2024

The DESTINY-Breast03 study: a plain language summary comparing trastuzumab deruxtecan with trastuzumab emtansine for breast cancer

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