Plain language summary of pegcetacoplan therapy in kidney transplant patients with C3G or primary IC-MPGN from the NOBLE study

This Plain Language Summary of Publication article (PLSP) from Future Rare Diseases describes the phase 2 NOBLE study, which examined adults with C3G or primary IC-MPGN who had received kidney transplants. These rare diseases involve C3 protein buildup in the kidneys, causing inflammation and damage that leads to kidney failure. Even after transplant, most patients continue accumulating C3 and redevelop the disease.

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This PLSP is based on an article called ‘Efficacy and Safety of Pegcetacoplan in Kidney Transplant Recipients With Recurrent Complement 3 Glomerulopathy or Primary Immune Complex Membranoproliferative Glomerulonephritis’ and was published in Kidney International Reports.

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• C3 glomerulopathy
• complement
• estimated glomerular filtration rate
• immune-complex membranoproliferative glomerulonephritis
• pegcetacoplan
• plain language summary
• Proteinuria