This Plain Language Summary of Publication article (PLSP) from Future Oncology, evaluated nirogacestat (Ogsiveo®) in 142 adults with progressing desmoid tumors. The study found that nirogacestat helped shrink tumors, reduce pain, lessen symptom severity, improve daily functioning, and enhance overall quality of life more than a placebo. However, participants taking nirogacestat experienced more side effects compared to those on a placebo.

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This PLSP is based on an article called ‘Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors’ and was published in the New England Journal of Medicine.

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