This plain language summary describes a clinical study that looked at the effects of a medicine called low-sodium oxybate (or LXB; XYWAV® [calcium, magnesium, potassium, and sodium oxybates]) in adults with narcolepsy. Narcolepsy is a rare brain disorder that can make people feel extremely sleepy during the day or have symptoms like cataplexy, which is sudden and temporary muscle weakness. This study compared changes in symptoms between people who either switched to placebo or continued with LXB after they had been taking LXB for 14 weeks. The placebo looked and tasted like LXB but did not have the active ingredient. This allowed researchers to see if LXB improved symptoms like cataplexy and extreme daytime sleepinessThis Plain Language Summary of Publication article from Future Neurology discusses a rare brain disorder called narcolepsy that can cause symptoms such as extreme sleepiness during the day or cataplexy (sudden and temporary muscle weakness). A study looked into whether taking a medication called low-sodium oxybate (LXB) for 14 weeks would improve these symptoms.

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The original article on which this summary is based is called ‘Efficacy and safety of calcium, magnesium, potassium, and sodium oxybates (lower-sodium oxybate [LXB]; JZP-258) in a placebo-controlled, double-blind, randomized withdrawal study in adults with narcolepsy with cataplexy’ and was published in Sleep. 

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