This Plain Language Summary of Publication article (PLSP) from Future Rare Diseases covers three clinical studies that tested once-weekly lonapegsomatropin injections in children with growth hormone deficiency (GHD). This new long-acting treatment provides a more convenient alternative to daily injections, helping children with GHD achieve normal growth and reach their target height.

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This PLSP is based on three articles:

‘Weekly Lonapegsomatropin in Treatment–Naïve Children With Growth Hormone Deficiency: The Phase 3 heiGHt Trial’ was published in JCEM.

‘Switching to Weekly Lonapegsomatropin from Daily Somatropin in Children with Growth Hormone Deficiency: The fliGHt Trial’ was published in Hormone Research Paediatrics.

‘Safety and Efficacy of Lonapegsomatropin in Children With Growth Hormone Deficiency: enliGHten Trial 2-Year Results’ was published in JCEM.

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