This is a summary of research studies (known as clinical trials) called SPIRIT 1 and SPIRIT 2. The SPIRIT 1 and SPIRIT 2 studies compared how well a medicine called relugolix combination therapy worked in relieving pain in women with moderate to severe endometriosis compared to a placebo, a pill with no active medication. Endometriosis occurs when tissue similar to what normally lines the uterus grows in other places, such as the ovaries, fallopian tubes, and bowelsThis Plain Language Summary of Publication article from Pain Management summarises two studies , SPIRIT 1 and SPIRIT 2, that compared how well a medicine called relugolix combination therapy worked to relieve pain in women with moderate to severe endometriosis. Endometriosis happens when tissue that is similar to what normally lines the uterus grows in other places, such as the ovaries, fallopian tubes and bowels.

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The original article on which this summary is based is called ‘Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind studies (SPIRIT 1 and 2)’ was published in The Lancet.

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