Trofinetide’s impact on communication in Rett syndrome: summary from the LAVENDER trial

This Plain Language Summary of publication article (PLSP) from Future Rare Diseases, discusses findings from the LAVENDER study, which examined whether trofinetide could improve communication in girls and young women with Rett syndrome, a rare genetic condition that impairs brain development and often results in the loss of verbal communication. The study focused on both spoken and nonverbal communication methods, such as body movements or eye-gazing, commonly used by individuals with Rett syndrome.

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This PLSP is based on an article called ‘Trofinetide Treatment Demonstrates a Benefit Over Placebo for the Ability to Communicate in Rett Syndrome’ and was published in Pediatric Neurology.

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• communication-related end points
• LAVENDER clinical trial
• lay summary
• plain language summary
• Rett syndrome
• trofinetide