Pegvaliase (PALYNZIQ®) is an enzyme injected under theskin to lower blood phenylalanine (Phe) levels in adults withphenylketonuria (PKU). PKU is a condition in which elevatedlevels of Phe in the blood and brain can affect the way a personthinks, feels and acts, and may impact their daily life. It iscommon for adults with PKU to experience anxiety. This can becaused by PKU itself as well as its management.This Plain Language Summary of Publication article (PLSP) from Future Rare Diseases discusses a treatment for adults with phenylketonuria (PKU). PKU is a condition that affects the way a person thinks, feels and acts and may impact the person’s daily life. Adults with PKU commonly experience anxiety, this can be caused by PKU itself and also it’s management. Pegvaliase is a treatment option for people with PKU, however, people with PKU may have anxiety surrounding this treatment, including starting the treatment and self-injecting. This summary discusses recommendations developed by healthcare professionals and people with PKU to manage anxiety through the treatment journey.

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This PLSP is based on an article called ‘Best practice recommendations for the management of anxiety during the pegvaliase journey’ that was published in Molecular Genetics and Metabolism. 

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