This plain language summary describes the phase 3 PRINCE study. The study looked at adults with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that is acquired (not inherited), usually during adulthood. PNH causes hemolysis, which is the destruction of red blood cells. This Plain Language Summary of Publication article from Future Rare Diseases describes a study called PRINCE. The study focused on adults with a rare blood disorder called paroxysmal nocturnal hemoglobinuria (PNH). The PRINCE study compared a new medicine called pegcetacoplan with the older treatment of supportive care (including red blood cell blood transfusions; blood thinners; steroid medicines; and supplements, like iron, folate or vitamin B12).

Visit the Future Medicine site using the link to read the full article.

The original article on which this summary is based is called d ‘Pegcetacoplan controls hemolysis in complement inhibitor–naive patients with paroxysmal nocturnal hemoglobinuria.’  and was published in Blood Advances. 

Visit the Ash Publications site using the link to read the article.