his is a summary of a review article about gene therapy. Review articles summarize many previously published scientific articles. The review was about how a common virus could change how one type of gene therapy works. It also discussed the importance of antibody testing for people who may receive gene therapy. The original review was published in Molecular Therapy in 2023This Plain Language Summary of Publication article from Future Rare Diseases summarises a review article about gene therapy (a type of medical treatment). One of the viruses used in gene therapy is called adeno-associated virus (AAV), however, a common reason why some people can’t receive this gene therapy is because they have antibodies against AAV. This article looks into how antibodies against AAV can prevent gene therapy from working and the potential side effects.

Visit the Future Medicine using the link to read the article.

The original article on which this summary is based is called ‘Binding and neutralizing anti-AAV antibodies: Detection and implications for rAAV-mediated gene therapy’ and was published in Molecular Therapy. 

Visit the Science Direct using the link to read the original article.