This plain language summary describes the results of a phase 1 research study (or clinical trial) called MonumenTAL-1 published in the New England Journal of Medicine in December 2022. A phase 1 study is an early clinical trial where researchers evaluate how safe a medicine is at different doses in  a  small  number  of  people.  In  the  MonumenTAL-1  study,  researchers  looked  at  a  new  medicine  under  development  called  talquetamab,  for  people living with multiple myeloma (a type of blood cancer) who did not respond (refractory), stopped responding (relapsed) or who had difficulty dealing with their previous treatments.This Plain Language Summary of Publication article from Future Oncology looks at a medicine called talquetamab. A study called MonumenTAL-1 evaluated how safe the medication was, at different doses, to treat people with multiple myeloma (a type of blood cancer) who did not respond (refractory), stopped responding (relapsed), or who had difficulty dealing with their previous treatments.

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The original article on which this summary is based was published in the New England Journal of Medicine. The article is called ‘Talquetamab, a T-Cell–Redirecting GPRC5D Bispecific Antibody for Multiple Myeloma’.

Read the original article here.