Rett syndrome is a rare genetic disorder that affects the way the brain develops. The medication trofinetide (DAYBUE™) was studied in a large clinical trial called LAVENDER, where it showed a benefit in reducing symptoms of Rett syndrome versus placebo (placebo did not contain medication but looked the same as trofinetide and was taken in the same way). The most common side effect in the trial was diarrhea (frequent and/or watery bowel movements). In order to help caregivers and healthcare providers, experts created recommendations on how to prevent and manage diarrhea if it occurs during trofinetide treatmentThis Plain Language Summary of Publication article from Future Rare Diseases looks at using trofinetide, a medication also known as DAYBUE™ , in reducing symptoms of Rett syndrome. Rett syndrome is a rare genetic disorder that affects the way the brain develops. Experts created recommendations on how to prevent and manage diarrhea ( the most common side effect in the study) if it occurs during trofinetide treatment.

Read the full article here.

The original on which this summary is based is called ‘Recommendations for the management of diarrhea with trofinetide use in Rett syndrome’ and was published in Expert Opinion on Orphan Drugs. 

You can read the original article here.